
Not every ingredient is a perfect match. Some combinations can negate each other’s benefits or even irritate your skin. Photo by cottonbro studio
We’ve all heard about the benefits of ingredients like Retinol, Vitamin C, Hyaluronic Acid, and Niacinamide for your skin. But do these powerhouses play well together? The answer is… it depends.
Not every ingredient is a perfect match. Some combinations can negate each other’s benefits or even irritate your skin. To maximize your skincare routine, explore some of the following ingredient pairings and those you should avoid.
Can Retinol Mix with Vitamin C?
Yes, you can use both retinol and vitamin C in your skincare routine. In fact, they can complement each other to achieve a more radiant and youthful complexion.
How to Use Them Together:
While you can use both ingredients, applying them at different times of day is generally recommended to maximize their effectiveness and minimize potential irritation.
- Vitamin C: Apply vitamin C serum in the morning to protect your skin from environmental stressors and brighten your complexion.
- Retinol: Apply retinol at night to stimulate collagen production and reduce the appearance of fine lines and wrinkles.
Why This Timing Works:
Daytime Protection: Vitamin C is a powerful antioxidant that helps protect your skin from free radical damage caused by sun exposure and pollution.
Nighttime Renewal: Retinol works best at night to promote cell turnover and collagen production.
Can AHA/BHA Mix with Niacinamide?
Yes, you can use niacinamide with AHAs and BHAs, but with caution.
While these ingredients can be powerful when used together, it’s important to consider a few factors:
- pH Levels: AHAs and BHAs are acidic, while niacinamide works best for your skin at a slightly alkaline pH. Combining them in the same product or applying them too close together can reduce the effectiveness of each ingredient.
- Potential for Irritation: Overusing AHAs, BHAs, and niacinamide can irritate the skin, especially for those with sensitive skin.
How To Use Them Together:
Here are some tips for using these ingredients together:
- Alternate Usage: Use AHAs/BHAs on one night and niacinamide on the next to minimize irritation.
- Time Your Application: Wait at least 30 minutes between applying AHAs/BHAs and niacinamide to allow the skin to adjust to the pH changes.
- Start Slowly: Introduce new products gradually to assess your skin’s tolerance.
- Moisturize Well: Hydrate your skin well to counteract the potential drying effects of AHAs and BHAs.
Can Hyaluronic Acid Mix with Niacinamide?
Yes, hyaluronic acid and niacinamide can be used together in a skincare routine. In fact, they complement each other well, providing hydration and brightening benefits. Hyaluronic acid is a humectant that draws moisture to the skin, keeping it hydrated and plump. At the same time, niacinamide is a form of vitamin B3 that helps regulate oil production, reduces inflammation, and improves skin tone.
How to Use Them Together:
- Layer Them: Apply hyaluronic acid first, followed by niacinamide. Hyaluronic acid creates a hydrating layer, allowing the niacinamide to penetrate deeper into the skin.
- Use Separate Products: Apply each product separately, waiting a few minutes between applications.
- Look for Combined Products: Some skincare products combine both hyaluronic acid and niacinamide for a convenient solution.
Other Skincare Ingredient Combos To Consider:
- Vitamin C and Ferulic Acid: This dynamic duo offers potent antioxidant protection. Vitamin C brightens the skin and boosts collagen production, while ferulic acid stabilizes vitamin C and enhances its effectiveness.
- Retinol and Hyaluronic Acid: Retinol is a powerful anti-ageing ingredient that can cause dryness. Pairing it with hyaluronic acid, a hydrating humectant, can help to minimize irritation and keep your skin moisturized.
Can You Mix Everything Together?
While it’s tempting to layer on multiple products, it’s important to consider potential interactions and sensitivities. Some combinations to avoid include:
- Retinol and AHA/BHA: Using these together can increase the risk of irritation and dryness.
- Vitamin C and Benzoyl Peroxide: These ingredients can neutralize each other’s effects.
The Order of Application:
Generally, you should apply products from thinnest to thickest consistency. Here’s a basic order:
- Cleanser
- Toner
- Treatment Serums (like vitamin C, retinol, or niacinamide)
- Hyaluronic Acid
- Moisturizer
- Sunscreen (daytime)
How To Start Mixing Your Skincare
- Patch Test: Always do a patch test before trying a new product or combination.
- Listen to Your Skin: Pay attention to how your skin reacts and adjust your routine accordingly.
- Consult a Dermatologist: If you have specific skin concerns, consult a dermatologist for personalized advice.
By understanding the science behind skincare ingredients as you begin to customize your routine, you can achieve a healthier, more radiant complexion. For professional treatments, My Bliss Clinic Aesthetic Clinic Malaysia can help! Aside from skincare and lifestyle consultations, we offer Fotona 4d, HIFU treatment and Botox in Kuala Lumpur, Malaysia. Schedule your appointment with us today!

Dr Elson Chee
Dr Elson Chee is the founder of My Bliss Clinic with more than 10 years of experience in aesthetic medicine and dermatology.