Noticing sagging around your jawline or cheeks? You’re not alone.

As we age, especially after our 30s, one of the most visible changes in the face is the gradual loss of volume in the lower third. This volume loss isn’t just about skin. It’s about the deeper fat layers that give your face youthful contours and lift.

Profhilo Structura is a next-generation injectable treatment specifically engineered to address this problem. Unlike traditional fillers that simply replace lost volume, Profhilo Structura works by stimulating your body to regenerate lost facial fat and collagen—a process known as lipo lifting.

Developed with patented NAHYCO® technology, it combines two types of hyaluronic acid (high and low) in a unique hybrid complex, designed to restore facial structure without excessive bulk. The result? Long-lasting improvements in facial firmness and skin elasticity.

This article explores how it works, what to expect, and why it’s quickly becoming a top choice for facial rejuvenation.

Table of Contents

What is Profhilo Structura? How Does It Work?
Targeted Treatment Areas
Am I a Suitable Candidate for Profhilo Structura?
Addressing Facial Sagging, Adipose Tissue Restoration, & Skin Lifting
What to Expect: Treatment Protocol, Injection Techniques, Results, & Longevity
Benefits of Profhilo Structura
Safety and Side Effects
Refresh and Rejoice Like Never Before

What is Profhilo Structura? How Does It Work?

Profhilo Structura is not your typical injectable. It’s an injectable bio-remodelling gel formulated to reverse age-related fat loss, specifically in the lower face, including areas like the cheeks, jawline, and perioral region.

Unlike volumising fillers that act like implants under the skin, Profhilo Structura triggers your body to rebuild its own volume by activating adipocytes (fat cells) and fibroblasts. It works by:

Regenerating Superficial Fat Tissue: Replenish facial compartments that deflate with age, restoring natural contours without overfilling.
Stimulating Collagen and Elastin Production: Add firmness and elasticity to the skin structure, improving lift and definition over time.
Supporting Long-Term Facial Architecture: Results develop gradually, giving a more authentic and rejuvenated appearance rather than a sudden or artificial one.

This process helps to restore lost volume associated with ageing, addressing fat depletion and volume loss for a more youthful appearance.

At My Bliss Clinic, we often pair Profhilo Structura with the original Profhilo (for skin hydration and glow) to deliver a synergistic effect: volume and lift from within, plus skin luminosity on the surface.

Targeted Treatment Areas

Profhilo Structura is effective for treating subcutaneous fat loss in the face, including the cheeks and preauricular area, which correspond to key facial fat compartments that are prone to age-related volume loss.

It can also be used to address facial hollowing, sagging skin, and loss of skin firmness in the lower face and jowls, restoring them for a more youthful appearance.

Profhilo Structura is a versatile treatment that can be tailored to individual needs and concerns. As such, it can be used in combination with Profhilo as well as other facial treatments such as dermal fillers, BTA, and laser treatments for an even more comprehensive rejuvenation.

Am I a Suitable Candidate for Profhilo Structura?

Ideal candidates include individuals aged 35 and above who are experiencing early to moderate signs of facial ageing.

This may include:

Volume loss and facial hollowing
Skin sagging or laxity
Fine lines and wrinkles

Profhilo Structura is a safer alternative for those who want natural-looking rejuvenation without the heaviness or overfilled look that can sometimes accompany traditional dermal fillers.

Addressing Facial Sagging, Adipose Tissue Restoration, & Skin Lifting

What sets Profhilo Structura apart is its ability to regenerate superficial fat compartments. It targets facial sagging by restoring adipose tissue and improving skin elasticity. This process is known as adipose tissue restoration, which helps to:

Rebuild natural facial contours
Improve skin tension and elasticity
Restore youthful definition without adding bulk

By treating both the skin and the fat layer beneath, this treatment delivers a subtle but transformative lift.

What to Expect: Treatment Protocol, Injection Techniques, Results, & Longevity

The procedure is minimally invasive and typically involves:

Initial Protocol: Two sessions spaced 30 days apart
Maintenance: Every 4–6 months for sustained results

A blunt-tip cannula is used to administer the injection, which reduces the risk of bruising and swelling. Injections techniques focus on restoring volume in hollowed regions of your lower face.

Visible improvements in skin quality and structure can be seen as early as 4 weeks after the first treatment. This treatment provides long-lasting results, with many patients experiencing its full effects after just two treatments.

Results can last 4–6 months, depending on individual factors like age, skin condition, and lifestyle. Maintenance sessions help preserve and prolong the benefits.

Most patients report minimal discomfort and can resume their normal activities immediately after treatment due to little to no downtime.

Benefits of Profhilo Structura

Profhilo Structura goes beyond temporary plumping. It addresses the root cause of lower face ageing by rejuvenating depleted fat compartments and encouraging natural tissue regeneration.

Key benefits of Profhilo Stuctura include:

Regeneration of Facial Fat Compartments

- Restores lost volume in areas like the cheeks, jawline, and perioral region by encouraging the body to rebuild superficial fat.

Enhanced Skin Firmness and Elasticity

- Stimulates collagen and elastin production for a noticeable lifting and tightening effect.

Natural-Looking Results Without Bulk

- Rather than adding external volume, it supports structural rejuvenation for a softer, more authentic outcome.

Minimally Invasive with Little Downtime

- Treatment involves precise injections with minimal discomfort and quick recovery.

Clinically Backed and CE-Marked

- Developed using patented NAHYCO® technology and approved for safety, making it a trusted choice among aesthetic professionals.

These benefits make Profhilo Structura a powerful solution for those seeking a holistic, subtle, and safe approach to reversing facial ageing. It offers a refined approach to facial sculpting without the heaviness or stiffness often associated with fillers.

Safety and Side Effects

Profhilo Structura is clinically tested and CE-approved, with a strong safety record. This treatment is well-tolerated, with most patients experiencing minimal discomfort during and after treatment.

Common side effects are mild and temporary, such as:

Redness
Swelling
Bruising at the injection site

These typically resolve within a few hours to a few days. Most patients can resume normal activities right after treatment.

Refresh and Rejoice Like Never Before

Profhilo Structura represents a new era in facial rejuvenation. It’s one that goes beyond surface-level improvements to address the deeper structural changes caused by ageing. By targeting both the skin and underlying fat compartments, it provides a comprehensive approach to lifting, firming, and restoring the face.

Its science-backed formulation and minimally invasive protocol make it a top choice for those who want natural, long-lasting results without surgery. Whether used alone or combined with other treatments, Profhilo Structura empowers patients to rediscover a more youthful, refreshed appearance with confidence.