Plinest & Newest

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Plinest and Newest are the first and original polynucleotides (PN), a DNA fragment extracted from ethically bred Italian Trout Fish using patented HPT technology by Mastelli, Italy. Polynucleotides is able to improve overall skin health from within, restoring skin radiance, youthfulness and elasticity by promoting skin bio-revitalization and collagen regeneration via a natural physiological process.

Plinest and Newest have been available in Europe since 2005 with US FDA approval and CE marked. Since 1952, Mastelli has over 70 years of research in PN-HPT (highly purified technology). It assures highest purification levels from the PN extraction process, resulting in superior efficacy while maintaining safety compliance at the highest pharmaceutical standards.


Plinest contains purely polynucleotides while Newest contains polynucleotides with hyaluronic acid. The addition of hyaluronic acid makes Newest more suitable for those with dry and wrinkly skin as  hydrating effect is being enhanced

Who are suitable to undergo this treatment?

This treatment is suitable for those with the following skin concerns:

  • Aging skin
  • Fine lines and wrinkles
  • Large pores
  • Acne scars / surgical scars
  • Pigmentation
  • Dry and dehydrated skin
  • Dull skin

Other than face and neck, Plinest and Newest can be used on body such as hands and abdomen.

How many sessions are required? How often do I need to have this treatment?

3 to 4 sessions are recommended for optimal results, treatment interval is 1 month apart. After completing 3 to 4 sessions, maintenance treatment is recommended once every 6 to 9 months.

What can I expect after the treatment?

2 to 3 weeks after the first session, you will notice improved skin firmness, skin more hydrated with reduced wrinkles and fine lines. Results will be further improved after the subsequent sessions.

Is there any downtime after the treatment? Is painful?

There will be some redness, swelling and needle marks after the treatment, which will resolve within hours. Occasionally there might be bruising, which takes up to a week to resolve.

Numbing cream will be applied on the treatment area prior to the injections. This will significantly reduce the discomfort you may feel during the procedure. Plinest and Newest can be injected either with needles or blunt cannula. The use of blunt cannula can further reduce the discomfort and downtime post procedure.

Can Plinest & Newest be combined with other aesthetic treatments?

Yes, they can be combined with other aesthetic treatments such as laser, dermal fillers, botulinum toxin and microneedling, with 2 to 3 weeks apart between these treatments. Clinical studies have shown that combined treatments provide better clinical outcomes

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Photos courtesy of Mastelli

Message from Dr. Elson

Both Plinest and Rejuran Healer are injectable polynucleotides. They are both high quality product and yield comparable clinical results. For better outcomes, polynucleotide treatment may be combined with other treatments such as Silkpeel Dermalinfusion, Fotona 4D laser or microneedling.